A member asked:

Please tell me can diphenhydramine make you feel itchy all over?

2 doctors weighed in across 2 answers

Unlikely: It should control your itch

Answered 8/17/2014

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Dr. John Chiu answered

Unlikely but: anything is possible. If you are already itching all over and try to take Benadryl (diphenhydramine) to control the itching, then the intense itching may just be progressing whether you take the Benadryl (diphenhydramine) or not. Try other antihistamine to see if they cause or relieve your itching. It has been suggested that the Benadryl (diphenhydramine) when applied topically may lead to allergic sensitization to the drug.

Answered 8/13/2017

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