Could cushings syndrome affect the penis if you had or have it causing changes like scaling painfully sensitivity thinning fragile skin for no reason?

May be...: Since Cusihing's syndrome displays a constellation of signs & symptoms resulting from long-term systemic effects of exposure to cortisol. a similar change to penile skin from its effects could not be exempted, and manifested in a wide range of texture depending on age, duration of exposure, general health, other comorbidities, nutrition, etc. For individual detail, ask & talk with Doc timely.