Gout sufferer allergic on both allopurinol and probenecid; what's next?

Two options: Colchicine may control the acute attacks while other medicines are started to lower uric acid levels which will ultimately prevent gout. One choice would be uloric which is a daily pill. If that fails, Krystexxa (pegloticase) is an an option. Krystexxa (pegloticase) is more powerful than other drugs but is given by intravenous infusion every two weeks.

Depends: You could try uloric, although a cross reactive allergy is possible. The next step if the gout was bad enough is pegloticase. You can also try losartan although the effect is mild (0.5 mg/dl). This also assumes you've already done all the lifestyle modifications like avoiding the wrong foods and drinks, exercise, weight loss, controlling comorbid diseases (psoriatic arthritis), etc.

Uloric or Krystexxa (pegloticase): Uloric works like Allopurinol and can be tolerated in many who are allergic to it. Krystexxa, (pegloticase) an infusion, is extremely helpful at first but l may not work long term in half of patients. Ask a rheumatologist.