A member asked:

What is the difference between actonel (risedronate) and fossamax?

A doctor has provided 1 answer
Dr. Arthur Heller answered

Specializes in Gastroenterology

Similar, but differ: Both are bisphosphonate drugs, taken orally, which decrease bone breakdown by osteoclast cells, and therefore increase bone density ;#40;a marker of bone strength;#41;. Different dosing, but can be weekly or monthly for either in osteoporosis. Were used in tumors in or to bone-now drugs mostly given IV for that. Fosamax (alendronate) stays in the system and bone longer; was thought to be more GI irritating ;#40;maybe not;#41;.

Answered 6/25/2014

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