A member asked:

Can you tell me how dendritic cells present their acquired antigens to t-cells in the thymus?

A doctor has provided 1 answer

Surface factors: DCs process and present antigen to activate both CD4+ and CD8+ T cells. Only DCs are capable of activating naïve T cells. Immature DCs lay dormant waiting to interact with foreign antigen. Once the antigen is captured, it is processed either by exogenous, endosomal or a proteosomal pathway. Antigen is taken up by phagocytosis or receptor mediated endocytosis into the cytosol. The antigen is further degraded in the cytosol via proteosome and enters the endoplasmic reticulum where peptides bind to newly synthesized MHC class I molecules for presentation on the cell surface. Here costimulatory molecules including members of the B7 family,and TNF family are present which are critical to the activation of T cells.

Answered 7/6/2014

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