What to do if muscle twitching/tiredness?

Can be many things: First thing to do is hydrate well and see if that makes a difference. If it does not, you should see your primary to check for basic causes, from continued dehydration to certain levels in your blood. If it continues, check with a neurologist or physiatrist to get an emg to rule out anything worrisome.

Rest/water: Your question is a bit too general for a precise answer, but in general, staying hydrate and providing adequate rest are good ideas to help with tired muscles.