Can i take oxycodone while on cymbalta (duloxetine)?oxycodone is an older prescription in my name but i have extreme pain today and hydrocodone isn't strong enough

Be careful: One of the potential side effects of Cymbalta (duloxetine) is Somnolence (daytime sleepiness). Oxycodone also has a similar side effect that can lead to drowsiness. When you take both drugs you might experience extreme sedation that could affect your ability engage in activities such as driving a car. Do talk with your physician about a strategy that would be safe and effective for breakthrough pain.