Be careful: One of the potential side effects of Cymbalta (duloxetine) is Somnolence (daytime sleepiness). Oxycodone also has a similar side effect that can lead to drowsiness. When you take both drugs you might experience extreme sedation that could affect your ability engage in activities such as driving a car. Do talk with your physician about a strategy that would be safe and effective for breakthrough pain.
Answered 8/15/2019
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