What is the difference between a primary stroke center and a comprehensive stroke center?

Staff available: This is a distinction used for treatment purposes and usually resolves to having a stroke neurologist in the hospital (not just on call), a neuroradiologist, and a number of other specialists who are involved in the management of an acute stroke patient. If you need to give thrombolytic treatments, they need to be given within very narrowly defined time frames.

None: Probably none, at least as far as one can tell from a name. Ask both centers what services they provide for acute stroke patients and then you decide!