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A member asked:
What causes parkinson's disease?
9 doctors weighed in across 2 answers
Unknown: The cause of parkinson disease is unknown. It appears that the cause of parkinson disease leads to the depletion of Dopamine in the subtantia nigra in the brain that is responsible for the symptoms of the disease.
Answered 6/25/2014
6.1k views
Further Detail: Polymers of a-synuclein protein form into "clumps" (intraneuronal inclusions) due to faulty "trash removal" processes in the neurons. As a result, cellular activity is disrupted. Other problems, such as oxidative stress causing mitochondria damage (energy producing portion of cell) lead to programmed cell death, or "apoptosis." many other facets of this cascade of problems are yet to be understood.
Answered 12/9/2013
5.7k views
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