Is there a problem or any risks or concerns in taking culturelle for digestive health once a day on a long-term and/or permanent bases?

No: It is just wise to re-evaluate why you are taking it. Pro-biotics are especially helpful after taking antibtiotics to restore friendly bacteria but the composition of one's diet has a much greater effect on the micro-flora of the intestinal tract. Eating 6 equal meals has a beneficial effect. Eating 7 servings of vegetables and and colorful fruits grow the right bacteria.