Do majority of people get cured for life with epididymitis? or do a lot of them have to take antibiotics for the rest of their lives?

Most cured of it: Both infectious and non- infectious causes of epididymitis exists. Infections with bacteria include E. coli, chlamydia, mycoplasma, and others. In certain cases, ejaculation may make thing better by "clearing the plumbing"; in others, if may make thing worse (rare) but it's best to talk to your urologist. The use of a scrotal support will also help, since it minimizes stress from "tugging".