No: No, a pregnancy wouldn't miscarry just because of diphenhydramine. Miscarriages are a normal part of having children, so many women have a miscarriage while creating their family. Some pregnancies make it to term, but others do not (that's what naturally happens). The Ob-Gyn doctor can investigate as to why, if he or she suspects an unusual problem causing the miscarriage.
Answered 9/1/2015
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