What would be a good tapering schedule for weaning off of 50mg of zoloft (sertraline)?

Why tapering?: You should talk to the doctor who prescribed it first, to make sure you don't still need the medication to control any symptoms. Otherwise, to taper, decrease to 25 mg daily for two weeks and then stop. You could start to notice a return of depression or anxiety with reducing the dose or stopping it. In that case, just restart it at 50 mg daily. Good luck!