What is the difference between physical dependence vs addiction?

Very little: I believe we are splitting hairs. Same thing. If you are physically dependent, that describes the hallmark of addiction. Hope this helps. Whatever you wish to call it, get help yesterday. Talk with your doctor the day before.

Physical vs mental: Physical dependence refers to the effects that occur with some substances ranging from Cocaine and nicotine to caffeine when someone who has been using them heavily try to stop. Addiction refers to a persistent need to keep doing something when you want to stop. Dependence may make that harder, but many addictions are psychological, with no physical consequences to stopping.

Big difference: Some medications given therapeutically can cause physical dependence. For instance, opioid pain medications taken consistently for ~30 days will cause the body to become physically accustomed to them. Tapering is needed. "addiction" means craving more ; more of the substance, focusing on obtaining ; using more -- often neglecting other life roles in the process. Big difference!