What is high positive cryoglobulins?

Can cause vasculitis: Can cause vasculitis, or blood vessel inflammation. There are three types, and each as its own set of disease associations. However, these proteins can cause lower extremity vasculitis, or a more widespread vasculitis. A search for a cause should be underway, and complement studies to see if associated blood vessel inflammation is present. It can be seen with rheumatoid, other ctds.