A member asked:

I took naproxen 500mg n hr ago can i take nyquil now? i don't feel good at all n can't sleep.

3 doctors weighed in across 2 answers

Pain caused insomnia: You are taking Naproxen an NSAID should not interfere with nyquil for sleep. Read the label for any warnings. I am not totally familiar with otc nyquil. Hope you feel better soon.

Answered 11/24/2015

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Dr. Heidi Fowler answered

Specializes in Psychiatry

Dear sleepless.: I checked this using the Drugs.Com drug interaction checker. I didn't know which type of Nyquil you were taking so I checked using "Vicks Nyquil Cough". There are no significant interactions between this form of Nyquil and Naproxen. You can use the drug interaction checker with the actual Nyquil product you are using.

Answered 10/26/2018

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