Sporadic malformatn: The fetal nervous system first forms as a groove that folds in on itself and begins to close from the middle outward to the top & bottom.If the bottom doesn't close, spina bifida develops. If the top doesn't, anencephaly occurs. Recurrence risk to any affected mom ~1-2% makes this non-genetic. There is some evidence that taking Folic Acid before pregnancy & up to 3m can help prevent it.
Answered 6/25/2014
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