Is it safe to take sertraline and mirtazapine together help please as have been taken both x?

Serotonin syndrome: I would advise against using both as there is a risk of serotonin syndrome - which can be dangerous -have you spoken to your psychiatrist ?

If prescribed, yes: Sometimes psychiatrists do use this combination, especially when someone is having a big problem with sleep along with anxiety/depression. If prescribed, your doctor will be keeping a watch on the doses and any potential signs of serotonin overload. Generally mirtazepine will be at a lower dose than the zoloft (sertraline). Please don't do this on your own, though.