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A 44-year-old female asked:
How exactly does sofosbuvir and ribavirin work to kill the hcv virus?
1 doctor answer • 2 doctors weighed in
Dr. Charles Cattanoanswered
Gastroenterology 41 years experience
Sovaldi + ribavirin: Sovaldi (sofosbuvir) is a uridine nucleotide analog prodrug that is converted in liver to an active metabolite that inhibits the hcv ns5b rna-dependent RNA polymerase, which is essential for viral replication. The combination is fda-approved, forms an aasld/idsa recommended treatment arm for multiple genotypes, as well as for hcv/hiv coinfected patients, ; those with liver cancer pre-transplant.
Created for people with ongoing healthcare needs but benefits everyone.
4.2k viewsReviewed >2 years ago
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CT
A 44-year-old female asked:
What is the difference between sofosbuvir and ribavirin in how they work against hcv?
1 doctor answer • 1 doctor weighed in
Dr. Robert Killiananswered
General Practice 30 years experience
Hep c: Do you have to be on treatment now? By the end of this year ribaviran will most likely no longer be used to treat hep vc. Treatments will be more effective and shorter in duration. Ribaviran is not directly active against hep c like sofosbuvir and the other amazing drugs coming this year.
Created for people with ongoing healthcare needs but benefits everyone.
4.2k viewsAnswered >2 years ago
Last updated Jun 10, 2014
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