A member asked:

How exactly does sofosbuvir and ribavirin work to kill the hcv virus?

A doctor has provided 1 answer

Sovaldi + ribavirin: Sovaldi (sofosbuvir) is a uridine nucleotide analog prodrug that is converted in liver to an active metabolite that inhibits the hcv ns5b rna-dependent RNA polymerase, which is essential for viral replication. The combination is fda-approved, forms an aasld/idsa recommended treatment arm for multiple genotypes, as well as for hcv/hiv coinfected patients, ; those with liver cancer pre-transplant.

Answered 6/10/2014

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