Can singulair, (montelukast) hydroxizine, or zyrtec cause elevated alk phos?

No elevation : Tiger, i can't find any evidence that any of those medications will increase your alk phos and i used them with patients regularly. Singulair (montelukast) is an anti-inflammatory used for asthma/allergies and it blocks certain areas of the inflammatory pathway. Both Hydroxyzine and zyrtec are traditional anti-histamines and block histamine binding to cells. Do you have elevated alk phos? Why was it checked?

Rare: That class of drugs has very few effects on the liver due to its nature of metabolism.