I am 46 and have had my period since i was 9 and now it comes every 25 days and the first few days i have to run to the bathroom with big clots help?

Changing Periods: You are premenopausal and your hormones are tapering and what you are going through may be normal physiological occurence.But discuss with your gynecologist at next visit.

Perimenopause: This is most likely related to the perimenopausal transition, however, you should see your doctor to see if a biopsy may be warranted. There are medications available that can alleviated your symptoms.