Depends on drug: To attack the CNS they have to cross the blood brain barrier. Not all drugs do this and it tends to be dose related as well as purity.
Answered 1/20/2017
5.9k views
Which drugs? Attack?: Many drugs act on the brain, some because they are meant to, others as side effects. Very few drugs damage the cns. The ones that are known to cause permanent changes are alcohol and stimulants like cocaine/crack and methamphetamine when used for long periods. Tolerance to opioids and benzodiazepines takes a year or so to disappear completely, but the effects are thengone.
Answered 5/1/2018
5.9k views
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