Why would there be an increase in wbc, chloride, glucose and decrease in creatinine and calcium in a patient who has has a colon cancer and is a smoke?

Not helpful: It's always a mistake to look at labs in isolation from the patient and from each other. Creatinine is most often low because the person has less muscle mass (wasting, slim lady), calcium most often low because Albumin is low (many causes). Wbc / glucose up from stress, infection, or other. As a lab specialist, please believe me that this is the wrong approach.

No connection: The lab values you quote can fluctuate and do not have any definitive relationship to colon cancer.