Could a lowlander adjust to permanently living at high altitude?

Certainly, Examples:: 1.Your bone marrow will makes more oxygen carrying red cells at altitude 2.The body produces more of a particular enzyme which increases release of oxygen from hemoglobin to the body tissues 3.Your kidneys adjust the acid base state of your body by changing amount bicarbonate (sodium bicarbonate) excreted. 4. Pulmonary capillary pressure increases, forcing parts of the lung to work that are dormant at sea level.