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A 42-year-old member asked:

Is seronegative rheumatoid joint disease as same as rheumatoid arthritis or is it something else?

3 doctor answers6 doctors weighed in
Rheumatology 34 years experience
It can be: In my clinic , we see a number of patients with rheumatoid arthritis but their testing for rheumatoid disease is within normal limits.They still lhave the same potential for inflammation and other complications of rheumatoid arthritis and we call the disease, seronegative rheumatoid arthritis. I believe in your question, the 2 illnesses are the same joint process or disease.
Dr. Angus Worthing
Internal Medicine 19 years experience
Better prognosis: Same disease. Seronegative rheumatoid arthritis (where rheumatoid factor and anti-ccp antibody tests are negative) generally has a better prognosis with a better response to medications and lower chance of joint damage. It is treated similarly to seropositive RA except that some biologic medications (rituximab, abatacept) may not work as well in seronegatives.
Dr. John Goldman
Rheumatology 56 years experience
Yes: A patient with a positive serology and rheumatoid arthritis can have severe disease. But also people who are seronegative can have severe damage. The highly positive seropositive patient can have more severe rheumatoid disease beyond the arthritis rheumatoid arthritis is a systemic disease of which arthritis is one manifestation. There can be systemic disease of eyes, lungs, heart to name some.
Last updated Jul 7, 2015


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