A member asked:

What is poorly differentiated squamous cell cancer?

12 doctors weighed in across 3 answers

Very malignnt.: This is a kind of squamous cancer that is poorly organized, or has no resemblance to what squamous lining should look like. It follows that this is a very serious cancer that must be treated very aggressively for any chance of a favorable outcome.

Answered 12/12/2019

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Dr. Kris Gast answered

Squamous cell: Well you are obviously reading a path report.This does not tell where the cancer cells are from.They are cancer..Hence the carcinoma.The cells are from squamous origin which is just how they look under the microscope.It means they could come from skin, lung cervix...Things that have that type of cell for a lining.The poorly means they look disorganized or angry.Not to give the cancer a personality.

Answered 4/18/2019

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It's a pathologic: Term, going from "well" sort of organized, tile-like patern even making 'pearls' of keratin, to "poorly" differentiated, less regular cell shapes, lost bridges between cells, even elongated mimicking a spindle/sarcoma like cell. Today cytokeratin ihc's help pin-point type and origin. It conveys being more prone to cause trouble.

Answered 4/4/2019

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