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A member asked:
How does klonopin (clonazepam) work on serotonin? i've heard it can contribute to depression. how so?
3 doctors weighed in across 2 answers
See details: It has not effect on serotonin. It can contribute to depression because it is a tranquilizer.
Answered 5/19/2015
4.6k views
Klonopin (clonazepam): Although klonopin's main action is on gaba-a receptors leading to inhibition of neuronal impulses, it also affects serotonin. It decreases 5ht utilization in the brain as well as egress of 5-hiaa from the brain. http://tinyurl.com/muqaacu it apparently upregulates serotonin transporters which do the opposite of ssri's -- take serotonin out of the synapse. Voila -- maybe more depression.
Answered 5/19/2015
4.6k views
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