Is schizencephaly a genetic disorder?

Sometimes it is: Schizencephaly is a birth defect of the brain with abnormal slits/clefts in the surface of the brain. The exact cause is unknown. There are some recurrences in a family which point to a genetic cause, and some genes have been reported in studies. But most of the time no genetic cause is found. It also depends on whether the patient has other findings, which would increase risk of genetic origin.