A member asked:

Is chronic urticaria a mast cell disease?

14 doctors weighed in across 3 answers

Urticaria: Urticaria, a clinically distressing disorder, is dermal oedema resulting from vascular dilatation and leakage of fluid into surrounding tissue, often in response to histamine (and other mediators) released from mast cells. A clear history of events surrounding the onset, together with laboratory investigations, in some cases allows us to find a cause and eliminate it.

Answered 1/11/2019

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Yes.: Mast cells are the source of histamine and other biologically active mediators that trigger hives.

Answered 4/9/2012

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Yes.: Mast cells are the source of histamine and other biologically active mediators that trigger hives.

Answered 9/29/2020

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