Yes to liver problem: Hydrocodone when in combination with tylenol (acetaminophen) can be injurious to liver. Tylenol (acetaminophen) is the culprit in this regard and the guidelines are that the ingested tylenol (acetaminophen) quantity should not exceed 4 gm/day. I am not aware of any known tylenol (acetaminophen) injuries to the kidneys.
Answered 2/18/2020
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