Can you tell me about hereditary spherocytosis?

Fragile RBCs: Hereditary spherocytosis (hs) is the most common inherited anemia in persons of northern european descent. It is caused by a mutation that changes the shape of red blood cells (rbcs) that makes them more fragile. Hs can range from almost no symptoms to more severe symptoms requiring blood transfusions. Sometimes splenectomy is required. A hematologist can advise you about what to look out for.