The safe combo: Tylenol (acetaminophen) 250mg+aspirin250mg+caffeine 65mg. Adults should not take more than 4000mg/day tylenol (acetaminophen). For Aspirin is the same amount, 4000mg/day max dose. Consuming 300 mg of caffeine per day is safe. The only caution is not to exceed 15 tablets per month, avoiding medication overuse headache. If you are concerned or experiencing serious side effects contact your pcp.
Answered 1/2/2015
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