A member asked:

Can you tell me the four types of receptors that are blocked by the phenothiazine drugs for psychosis.?

A doctor has provided 1 answer
Dr. Pamela Pappas answered

Specializes in Psychiatry

Receptors: Chlorpromazine (the first phenothiazine antipsychotic) blocks more than 4 receptor types: d2, h1, m1, alpha1, alpha2, 5ht2a, and 5ht2c -- and a very small amount of 5ht1a. Other agents also block d2 receptors, but vary in histaminic, muscarinic, and serotonergic receptor effects. These differences relate to differences in side effect profiles.

Answered 6/24/2014

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