A member asked:

Can you tell me the four types of receptors that are blocked by the phenothiazine drugs for psychosis.?

A doctor has provided 1 answer
Dr. Pamela Pappas answered

Specializes in Psychiatry

Chlorpromazine (the first phenothiazine antipsychotic) blocks more than 4 receptor types: d2, h1, m1, alpha1, alpha2, 5ht2a, and 5ht2c -- and a very small amount of 5ht1a. Other agents also block d2 receptors, but vary in histaminic, muscarinic, and serotonergic receptor effects. These differences relate to differences in side effect profiles.

Answered Jun 24, 2014

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