Can you tell me the risk factors for maple syrup urine disease?

Your genes: Msud is a genetic disorder. It occurs about 1:300000 although in some populations like mennonites the risk is as high as 1:300. There are multiple different genes associated with this disorder but all are involved in the metabolism of branched chain amino acids. The risk of having msud depends on the carrier status of your parents. Similarly, the risk to offspring depends on your carrier statu.