A 36-year-old member asked:
Hello docs, is angelman syndrome inherited or a disorder?
2 doctor answers • 3 doctors weighed in
Dr. Anna-Kaisa Niemianswered
Clinical Genetics 17 years experience
Most of the time not: Angelman syndrome, while it is a genetic condition, is rarely inherited and thus the risk of it happening again in other children of the same parents is very low, .
4.2k viewsReviewed >2 years ago
Dr. Richard Robertsanswered
Pediatrics 47 years experience
Sometimes: Some cases are due to a mutation carried by the mother. Most are due to spontaneous mutations or epigenetic events in the fertilized egg. So, the risk of Angelman may be inherited, but the disease may be genetic or due to epigenetic factors. It is one of the most complex genetic mechanisms yet discovered, and a clinical geneticist must analyze whether other family members are at up to 50% risk
2.7k viewsAnswered >2 years ago
1 comment
Dr. Richard Roberts commented
Pediatrics 47 years experience
Provided original answer
For a complete review, see http://www.ncbi.nlm.nih.gov/books/NBK1144/
Jun 24, 2015
Similar questions
A 47-year-old member asked:
Please tell me if angelman syndrome is inherited or a disorder?
2 doctor answers • 3 doctors weighed in
Dr. Alan Alianswered
Psychiatry 33 years experience
Angelman syndrome: It is a Neuro-genetic disorder resulting from abnormality of genes on Chromosome 15 .
3k viewsAnswered >2 years ago
Last updated Jun 24, 2015
People also asked
Connect with a U.S. board-certified doctor by text or video anytime, anywhere.
24/7 visits - just $39!
50% off with $15/month membership
Disclaimer:
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.