A member asked:

Is there any ssri/snri which is supposedly safer for a bipolar patient -with least chance of hypomania?

4 doctors weighed in across 3 answers

I don't like any: Literature does not support a benefit of adding any antidepressant (ad) to a mood stabilizer (ms) for bipolar disorder. Some experts go so far as to say that ads are fundamentally destabilizing, and that a trial of a ms is spoiled by the presence of an ad. That said, many people continue to require an ad. Ssris, especially paxil, (paroxetine) are safer than snris wrt hypomania. I would try seroquel first.

Answered 4/16/2016

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SNRIs for Bipolar?: Only physicians can recommend which medication to use. However, as snris can trigger manic episodes in bipolar disorders (likely because of the norepinephrine), i would suggest you keep the tegretol and Lamictal but ask your doc to consider switching the Cymbalta to a ssri for your depressive episodes. For examples, see: http://www.Drugs.Com/comments/duloxetine/for-bipolar-disorder.Html.

Answered 5/22/2015

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Dr. Alan Ali answered

Specializes in Psychiatry

Antidepressants/Mani: That varies with the patient, how well their moods are controlled, what medications they are on, and if other medical conditions exist. Review with your doctor.

Answered 5/22/2015

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