Several ways: In very severe prolonged asthma: if you become hypoxic (low oxygen) and acidotic (build up of carbon dioxide), your heart may go out of rhythm (fibrillate) and stop. Over many years of copd, the damaged lungs cause elevated pressure in the pulmonary artery causing the right ventricle to thicken (cor pulmonale), enlarge, and fail.
Answered 1/19/2018
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