Is it possible for my baby to have a meconium plug without any underlying health issues? all his newborn screening tests came back normal. plus, he stools on his own.

Yes: Yes, it's possible to have a meconium plug and not a serious condition like cystic fibrosis or bowel disease, but it's best to have the testing done to be sure.

Word definitions: To be more specific, all infants have a little plug that passes with the initial meconium.Occasionally the plug and some meconium passes before birth as a sign of stress.Meconium ileus is a condition where the meconium is so thick and sticky that it blocks all stool passage and can be a sign of cf. My state state screens for CF as part of its newborn screening program but not all do.