Should i be worried about smoking weed on accutane?

It's your business: It's now legal in some places and if you want to get goofy, it's your business. I couldn't find anything to suggest a drug interaction, but you've had the heads-up about weird things happening to your mood on Isotretinoin and some weed-smokers get the blues while coming off the buzz. Be a responsible adult. Maybe you can even get "high on life" instead.