Any good reasons a dr wouldn't want to trial naloxone/narcan off label for a few doses? (for depersonalization)

Lack of familiarity: Most physicians who do not want to prescribe a medication off label don't prescribe because of a lack of familiarity or lack of comfort in using a particular medication. Another reason could be lack of education and there you can provide help by providing the doctor with the necessary journal articles.www.ncbi.nlm.nih.gov/pubmed/15876908 1. J clin psychopharmacol. 2005 jun;25(3):267-70. :). There is no particular medical reason not to give the patient a trial on this.

Need good research : "An open trial of naltrexone in the treatment of depersonalization disorder." was a small trial wi only 14 subjects, would not be sufficient to convince me that treating a patient wi Narcan for depersonalization is the best way to go. https://www.ncbi.nlm.nih.gov/pubmed/15876908 As a psychiatrist I would use standard treatments until there is strong research / evidence to support use of Narcan.