I'm on my week of inactive birth control pills. if i take a fluconazole 150mg tablet, will it make my birth control less effective?

Birth control pills: There is no evidence to suggest that it would. If anything, other azole antifungals (like ketoconazole) inhibit the pathway in the liver that metabolizes your birth control pill, i.e. Make more of the pill available not less. The only antibiotic that was shown to reduce efficacy of birth control was rifampin, which speeds up the metabolic pathway in the liver.