Which bisphosphonate has the best efficacy & safety profile?

good question but...: That is a good question, but difficult to answer. They all have long-term effects, so it will be a long time before answers are known. It is a question to discuss with your doctor. Get a second opinion if you have lingering concerns.

Bisphosphonate: Bisphosphonate have been shown in studies to have an improvement in bone density in over 75 percent no direct comparison but anecdotally tv last seems to have the best record it has to be given intravenously.