HealthTap Online Primary Care Doctors Accepting New Patients
Book a video visit
HealthTap
Telehealth
A member asked:

Can a pill like spironolactone affect effectiveness of bipolar meds? i feel as if i'm edgy, and very sensitive. also feeling depressednow.

A doctor has provided 1 answer

It depends: On what medication it is. Spironolactone with lithium can increase levels of lithium. If used with other drugs like ssri or the class of maoi or antipsychotic drugs, it can increase risk for low sodium. If you are not feeling well, pls talkto your dr right away. Dose change or even med change may be needed. Be well.

Answered 9/29/2016

4.8k views

Thank

Related Questions

A member asked:

Is it still classified bipolar if you have states of extreme irritability instead of actually being 'manic'?

A doctor has provided 1 answer

A member asked:

Can doxycycline hyclate 100g and/or spironolactone 100g decrease the effectiveness of birth control pill (Junel fe 1.5/30)? I take bc daily but had sex without condom (did not finish inside). how much less effective is the pill? Should i get plan b?

A doctor has provided 1 answer

A member asked:

Can doxycycline hyclate 100g and/or spironolactone 100g decrease the effectiveness of birth control pill (Junel fe 1.5/30)? I take bc pill daily but had sex without condom (did not finish inside) 2 days after ovulation (had sex on day 16)

A doctor has provided 1 answer

A member asked:

HELP QUICK, I'm bipolar feeling like doing crazy things. driving fast pills . police chase! don't care. feels like someone is pulling on my chest.

A doctor has provided 1 answer

A member asked:

I started on 25mg's of Aldactone, (spironolactone) diarrhea began, then cut in half, now I cant sleep!! What now? Im sensitive to all meds.

A doctor has provided 1 answer

Sponsored Content
HealthTap Medical Group does not endorse products or services. Sponsored content revenues support our mission to make health information free and accessible to all.Learn more

People also searched for:

I take Depakote for bipolar- i think i start feeling edgy or as if its getting close to needing my next dose. Is it normal & doe's it wear off?
I have bipolar 1 and am having a hard time recently managing irritability and anxiety any meds you can recommend?
Are behavioral side effects possible (irritability, anger, etc) on 200 mg of lamictal for bipolar ii? Is this possible on such a non-activating drug?
I have Bipolar I. I also have bad irritability, does that come with Bipolar because I also have a lot of other stress?
Would Abilify (aripiprazole) help with mixed states and extreme irritability in bipolar ii?

Telemedicine

Primary Care
Manage Your Conditions
Women's Health
Children's Health
Men's Health
Senior Health
Wellness, Prevention & Lifestyle
Sexual Health
Mental & Behavioral Health
Travel Medicine
Urgent Care
Ask your question
Didn't find what you're looking for?

90,000 U.S. doctors in 147 specialties are here to answer your questions or offer you advice, prescriptions, and more.

Ask your question

More of what we treat

Allergies
Antibiotics
Asthma
High Blood Pressure
Prescriptions
Type 2 Diabetes
Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.
HealthTap
HIPAA logo
HIPAASecure
Soc 2 Type 2 logo
SOC 2 Type 2Certified
JCAHO Accredited
JCAHOAccredited
Member App

Download HealthTap

Video visit and message your doctor

Member App QR Code
Play Store Member LinkApp Store Member Link

Questions?

+1 (888) 828-0841support@healthtap.com
LinkedInTwitter
HomeTermsPrivacyCookiesDMCAHealth TopicsDoctors DirectoryDoctor Q&A by Specialty
Copyright 2026 HealthTap, Inc.