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A member asked:
Why do iron infusions make your bones ache?
A doctor has provided 1 answer
Marrow RBC expansion: Iron is a critical, rate limiting substrate in red blood cell (rbc) production in the bone marrow. Expansion of bone marrow cells/elements likely activates myelinated and unmyelinated sensory neurons. Similar pain can be seen with administration of (some, but not all) chemokines that stimulate the production of progenitor cells(eg g-csf for neutrophils).
Answered 10/19/2018
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