Is adderall (dextroamphetamine and racemic amphetamine) and tramadol safe to take together?

Probably but caution: Is good. Monitor impact. Take only as directed by your prescriber. Both may affect serotonin. Tramadol may cause sedation and Adderall (dextroamphetamine and racemic amphetamine) reduces sedation. Drugs.Com notes that the risk of seizures may be increased during co-administration of tramadol with any substance that can reduce the seizure threshold, such as central nervous system stimulants. Best regards.