A member asked:

Would neurofibromatosis type 1 disqualify me from donating sperm to a sperm bank?

4 doctors weighed in across 3 answers

Yes: You will be disqualified as a sperm donor, during screening process. Sperm bank will not accept people with any genetic disorders. Nf-1 is a genetic disorder involving chromosome 17, formerly known as ' von recklinghausen disease '.

Answered 9/28/2016

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Probably: As you know, neurofibromatosis type 1 (nf1) can affect some people mildly, but in others it can cause serious birth defects. The chance that a sperm donor might pass the nf1 mutation to his biological child is 50% for each pregnancy. This would probably be considered an excessively high risk, so i suspect that sperm (and egg) donors with confirmed nf1 would not be invited to donate.

Answered 4/11/2014

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Dr. Gerald Mandell answered

Specializes in Nuclear Medicine

Probably: Therefore 1 in 1500 are new cases.Neurofibromatosis type 1 is considered to have an autosomal dominant pattern of inheritance. People with this condition are born with one mutated copy of the NF1 gene in each cell. In about half of cases, the altered gene is inherited from an affected parent. Estimated incidence of NF1 is 1 in 3000. Approximately half of affected individuals represent first cases in the family as a result of a new genetic event or mutation.

Answered 12/15/2014

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