Will painkillers help with pain on elbow and in knuckle?

Yes and no: The answer really depends on the type of pain you are having. There's a difference between arthritic pain, tendinitis, muscle soreness, and ligamentous instability. The type of medication use would vary depending on the source of the pain which would require a focused physical exam, an mri, and an x-ray. We would combine this with the physical exam and history findings to come up with the best possible plan. It may involve injections, surgery, bracing, as well as, medication usage.

Generally, yes: Painkillers, also known as analgesic medications, come in many forms. Generally, these medications will help with pain from a musculoskeletal cause such as that affecting the elbow or hand.