Question 1

explain fragile x?

Accepted Answer

Genetic condition: Fragile x syndrome is a genetic condition involving changes in part of the x chromosome. This is the most common form of inherited mental retardation in males. Changes in the chromosome alter the correct amount of protein in your brain.

Question 2

what are the signs of fragile x among toddlers?

Accepted Answer

Variable: Fragile X impairs intellectual functioning to a varying degree.  Typical problems noted in children include hyperactivity, speech/language problems, learning disorders and anxiety.  Many of these conditions overlap with normal developmental stages in toddlers, so it may be difficult to sort out at this early age.

Question 3

how do you test for fragile x?

Accepted Answer

Blood: Cytogenetics and molecular techniques have been used to determine carrier status in fragile x.

Question 4

can you tell me if i am a carrier of fragile x will my son have higher chances of down syndrome?

Accepted Answer

Unlikely to happen: The defect that defines your carrier state and could pass to your son is a separate risk from that of ds, not affected by the fragile x. At 35-36 you have a separate risk of about 1% of trisomy 21, while your risk of passing the abnormal x to a son would be 50%. This is the same for a ds daughter with a similar (50%) risk of passing the carrier state to her.

Question 5

can you tell me what you suggest if you are a carrier of fragile x, will your son have higher chances of down syndrome?

Accepted Answer

Unrelated: Fragile x and Down syndrome are unrelated conditions.  Down syndrome is due to an extra copy of chromosome 21, most typically trisomy 21.  Most cases of fragile x are due to a mutation of the fmr1 gene which is located on the x chromosome.

Question 6

what kind of mental retardation does fragile x boy have?

Accepted Answer

Same as nonFragile X: Mental retardation simply refers to overall cognitive delay.  Fragile x is an identifiable genetic disorder that, in males, is associated with mild to moderate mr.  Those with fragile x do have other unique features, but the mr really is not especially different from mr caused by other factors.

Question 7

were a lot of people with fragile x misdiagnosed in the past?

Accepted Answer

Fragile x: I think many things past and present can be misdiagnosed. Especially when genetics are involved. Research and technology making it better every year.  This article may help. http://autismandoughtisms.wordpress.com/2011/08/04/genetic-origins-of-autism-when-is-autism-not-autism-fragile-x-and-rett-syndrome/.

Question 8

need help. is 9 months too early to determine if my nephew has a problem such as fragile x?

Accepted Answer

Easy study: If you have a family history that raises this concern a cheek swab can be sent for the fragile x study.Access to the proper lab kit to obtain the swab can be arranged by your pcp or s/he can refer you to a location where this can be done.An evaluation by a clinical geneticist or developmental pediatrician may be more helpful in the long run & encompass a broader understanding of babies needs.

Question 9

what causes of fragile x syndrome?

Accepted Answer

Gene mutation: Fragile x syndrome is due to a mutation within the fmr1 gene on x chromosome.  Part of the gene gets repeated too many times. It is the most common genetic cause of intellectual disability. Please see: http://www.Ncbi.Nlm.Nih.Gov/pubmedhealth/pmh0002633/ and http://www.Fragilex.Org/ for more information.

Question 10

how prevalent is fragile x syndrome?

Accepted Answer

See below: Fragile x syndrome is the most frequent form of inherited  intellectual disability.  The prevalence in men runs from 1 in 4, 000 to 1 in 6.000.  The prevalence in  women is estimated  at 1 in 10.000.

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A member asked:

Explain fragile x?

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What are the signs of fragile x among toddlers?

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How do you test for fragile x?

A member asked:

Can you tell me if i am a carrier of fragile x will my son have higher chances of down syndrome?

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Can you tell me what you suggest if you are a carrier of fragile x, will your son have higher chances of down syndrome?

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What kind of mental retardation does fragile x boy have?

A member asked:

Were a lot of people with fragile x misdiagnosed in the past?

A member asked:

Need help. is 9 months too early to determine if my nephew has a problem such as fragile x?

A member asked:

What causes of fragile x syndrome?

A member asked:

How prevalent is fragile x syndrome?

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