A 41-year-old member asked:
Can you tell me what you suggest if you are a carrier of fragile x, will your son have higher chances of down syndrome?
1 doctor answer • 1 doctor weighed in
Pediatric Cardiology 38 years experience
Unrelated: Fragile x and Down syndrome are unrelated conditions. Down syndrome is due to an extra copy of chromosome 21, most typically trisomy 21. Most cases of fragile x are due to a mutation of the fmr1 gene which is located on the x chromosome.
4.4k viewsAnswered >2 years ago
A 35-year-old member asked:
Can you tell me if I am a carrier of fragile x will my son have higher chances of down syndrome?
2 doctor answers • 2 doctors weighed in
Pediatrics 46 years experience
Unlikely to happen: The defect that defines your carrier state and could pass to your son is a separate risk from that of ds, not affected by the fragile x. At 35-36 you have a separate risk of about 1% of trisomy 21, while your risk of passing the abnormal x to a son would be 50%. This is the same for a ds daughter with a similar (50%) risk of passing the carrier state to her.
4.1k viewsAnswered >2 years ago
Last updated Feb 18, 2015
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