Question 1

which organ systems are affected by osteogenesis imperfecta?

Accepted Answer

Collagen formation: Oi refers to a group of individual genetic errors, which are associated with a variety of collagen formation.  Collagen is the mechanical foundation of body structure. Since the structure of bone depends on the mineralization of a complex called osteoid which is based on collagen, skeletal abnormalities, including deformity and fragility, are one of the most distressing characteristics of oi.

Question 2

could anybody get osteogenesis imperfecta?

Accepted Answer

No: It's a genetic disease, u do not get it as in infection.

Question 3

how is osteogenesis imperfecta inheritanced?

Accepted Answer

Autosomal dominant: Osteogenesis impecta (OI) is transmitted in autosomal dominant fashion.  Rare cases of OI,  type II B &amp;and type II C, are transmitted in autosomal recessive inheritance.

Question 4

what are the types of osteogenesis imperfecta?

Accepted Answer

Osteogenesis...: There are several types of osteogenesis imperfecta (OI). Type I is the mildest and most common form of the disorder. It accounts for 50 percent of the total OI population.

More information on each type can be found from the OI Foundation website. http://www.oif.org/site/PageServer?pagename=AOI_Types
Talk with your pediatrician or a geneticist for more specific info.

Question 5

does a karyotype show osteogenesis imperfecta?

Accepted Answer

No: A karyotype is useful for detecting chromosomal abnormalities where the number of actual chromosomes is abnormal (e.g., Down syndrome or turner syndrome) or a large defect in a chromosome (like a duplication or translocation).  Oi is caused by small mutations in a number of possible genes.  There are some prenatal tests available for oi.

Question 6

what happens if i have osteogenesis imperfecta?

Accepted Answer

Depends   : It really depends on what type you have. Here is some information:

http://emedicine.medscape.com/article/947588-overview

Question 7

how many types of osteogenesis imperfecta are there?

Accepted Answer

There are 8 types: Dominantly Inherited
Type I:Mildest form ~ 50% of total. 
Type II:Most severe form. High mortality rate
Type III:Most severe type who survives neonatal period.
Type IV: Moderate-severe growth retardation
Type V: Moderate in severity. Hypertrophic calluses
Type VI:Rare.Similar symptoms to OI Type IV
Resessively inherited  Types VII and VIII
Type VII resembles  IV and II
Type VIII similar to II, III

Question 8

what type of inheritance for osteogenesis imperfecta?

Accepted Answer

Autosomal dominant: Which means one copy of the altered gene in each cell is sufficient to cause the condition. 
And less comnnly autosomal recessive type of inhertance which means two copies of the gene in each cell are altered. The parents of a child with an autosomal recessive disorder typically are not affected, but each carry one copy of the altered gene.

Question 9

what can be done for people with osteogenesis imperfecta?

Accepted Answer

Manage the sysmtops: There is not yet a cure for oi. Treatment is directed toward preventing or controlling the symptoms, maximizing independent mobility, and developing optimal bone mass and muscle strength. Care of fractures, extensive surgical and dental procedures, and physical therapy are often recommended for people with oi. Use of wheelchairs, braces, and other mobility aids is common.

Question 10

what is the medical definition of osteogenesis imperfecta?

Accepted Answer

See below: Osteogenesis imperfecta (oi) is a congenital disease that is present at birth. It is commonly caused by genetic defect in type 1 collagen, a building block of bone. There are various defects that can affect this gene. The severity of OI depends on the specific defect in the gene. OI is an autosomal dominant disease.

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Which organ systems are affected by osteogenesis imperfecta

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Which organ systems are affected by osteogenesis imperfecta?

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Does a karyotype show osteogenesis imperfecta?

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What happens if i have osteogenesis imperfecta?

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How many types of osteogenesis imperfecta are there?

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